Identity
HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
F730038I15Rik,FOAP-2,P101-PI3K,p101
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23533
MIM: 611317
HGNC: 30035
Ensembl: ENSG00000141506
Variants:
dbSNP: 23533
ClinVar: 23533
TCGA: ENSG00000141506
COSMIC: PIK3R5
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA24686 | AKT3 | Gene | Pathway | associated | |||
| PA29457 | HRH2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38720074 | 2024 | Targetable leukaemia dependency on noncanonical PI3Kγ signalling. | 0 |
| 38720074 | 2024 | Targetable leukaemia dependency on noncanonical PI3Kγ signalling. | 0 |
| 34775477 | 2022 | PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors. | 3 |
| 34775477 | 2022 | PIK3R5 genetic predictors of hypertension induced by VEGF-pathway inhibitors. | 3 |
| 33493514 | 2021 | G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers. | 9 |
| 34187569 | 2021 | HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. | 5 |
| 33493514 | 2021 | G protein βγ translocation to the Golgi apparatus activates MAPK via p110γ-p101 heterodimers. | 9 |
| 34187569 | 2021 | HCP5, as the sponge of miR-1291, facilitates AML cell proliferation and restrains apoptosis via increasing PIK3R5 expression. | 5 |
| 26173259 | 2015 | Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. | 9 |
| 26173259 | 2015 | Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity. | 9 |
| 25374236 | 2014 | Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma. | 3 |
| 25374236 | 2014 | Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma. | 3 |
| 24014027 | 2013 | p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. | 20 |
| 24014027 | 2013 | p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. | 20 |
| 22065524 | 2012 | A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. | 15 |
Citation
Dessen P
PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49880/pik3r5
