SERPINE2 (serpin family E member 2)

2007-12-01  

Identity

HGNC
SERPINE2
LOCATION
2q36.1
LOCUSID
5270
ALIAS
GDN,GDNPF,PI-7,PI7,PN-1,PN1,PNI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5270
MIM: 177010
HGNC: 8951
Ensembl: ENSG00000135919

Variants:

dbSNP: 5270
ClinVar: 5270
TCGA: ENSG00000135919
COSMIC: SERPINE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135919ENST00000258405P07093
ENSG00000135919ENST00000258405A0A024R451
ENSG00000135919ENST00000409304P07093
ENSG00000135919ENST00000409304A0A024R498
ENSG00000135919ENST00000409840P07093
ENSG00000135919ENST00000409840A0A024R498
ENSG00000135919ENST00000423446C9JRK5
ENSG00000135919ENST00000432738C9JN98
ENSG00000135919ENST00000447280P07093
ENSG00000135919ENST00000454956C9K031

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Dissolution of Fibrin ClotREACTOMER-HSA-75205

References

Pubmed IDYearTitleCitations
383836572024Integrating artificial intelligence in osteosarcoma prognosis: the prognostic significance of SERPINE2 and CPT1B biomarkers.0
384079422024SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation.3
383836572024Integrating artificial intelligence in osteosarcoma prognosis: the prognostic significance of SERPINE2 and CPT1B biomarkers.0
384079422024SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation.3
367977692023Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-????B-IL-6 axis of tumor-associated macrophages.14
377297022023Microdissection of cancer-associated fibroblast infiltration subtypes unveils the secreted SERPINE2 contributing to immunosuppressive microenvironment and immuotherapeutic resistance in gastric cancer: A large-scale study integrating bulk and single-cell transcriptome profiling.1
367977692023Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-????B-IL-6 axis of tumor-associated macrophages.14
377297022023Microdissection of cancer-associated fibroblast infiltration subtypes unveils the secreted SERPINE2 contributing to immunosuppressive microenvironment and immuotherapeutic resistance in gastric cancer: A large-scale study integrating bulk and single-cell transcriptome profiling.1
346488812022SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.25
353568802022[Bioinformatic analysis of immune correlation and prognostic value of SERPINs in glioma].1
365050992022Upregulation of SERPINE2 Results in Poor Prognosis of Hepatoblastoma via Promoting Invasion Abilities.2
346488812022SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.25
353568802022[Bioinformatic analysis of immune correlation and prognostic value of SERPINs in glioma].1
365050992022Upregulation of SERPINE2 Results in Poor Prognosis of Hepatoblastoma via Promoting Invasion Abilities.2
337601352021SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells.3

Citation

Dessen P

SERPINE2 (serpin family E member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49888