TIMELESS (timeless circadian regulator)

2007-12-01  

Identity

HGNC
TIMELESS
LOCATION
12q13.3
LOCUSID
8914
ALIAS
TIM,TIM1,hTIM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8914
MIM: 603887
HGNC: 11813
Ensembl: ENSG00000111602

Variants:

dbSNP: 8914
ClinVar: 8914
TCGA: ENSG00000111602
COSMIC: TIMELESS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111602ENST00000229201Q9UNS1
ENSG00000111602ENST00000553532Q9UNS1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381780942024TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.0
382615682024ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosis.0
383541742024SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.0
388010732024The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation.0
381780942024TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.0
382615682024ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosis.0
383541742024SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.0
388010732024The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation.0
360990622023Regulation of mineralocorticoid receptor activation by circadian protein TIMELESS.0
371445182023Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe.3
373404612023TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer.1
374333642023TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation.2
380531432023An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker.0
360990622023Regulation of mineralocorticoid receptor activation by circadian protein TIMELESS.0
371445182023Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe.3

Citation

Dessen P

TIMELESS (timeless circadian regulator)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49895/favicon/js/lib/teaching-explorer/