TRIM45 (tripartite motif containing 45)

2007-12-01  

Identity

HGNC
TRIM45
LOCATION
1p13.1
LOCUSID
80263
ALIAS
RNF99

Other Information

Locus ID:

NCBI: 80263
MIM: 609318
HGNC: 19018
Ensembl: ENSG00000134253

Variants:

dbSNP: 80263
ClinVar: 80263
TCGA: ENSG00000134253
COSMIC: TRIM45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134253ENST00000256649Q9H8W5
ENSG00000134253ENST00000369461Q5T2K3
ENSG00000134253ENST00000369464Q9H8W5
ENSG00000134253ENST00000485032S4R407
ENSG00000134253ENST00000497970H0YCA7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
387553082024TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation.0
387553082024TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation.0
380371612023TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.3
380371612023TRIM45 aggravates microglia pyroptosis via Atg5/NLRP3 axis in septic encephalopathy.3
316634682020TRIM45 Suppresses the Development of Non-small Cell Lung Cancer.9
316634682020TRIM45 Suppresses the Development of Non-small Cell Lung Cancer.9
285421452017TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.29
285421452017TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.29
246819542015The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.20
246819542015The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.20
226340062012TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.22
226340062012TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.22
153516932004TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.17
153516932004TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.17

Citation

Dessen P

TRIM45 (tripartite motif containing 45)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49910