DUSP10 (dual specificity phosphatase 10)
2010-05-01 Larisa Nonn AffiliationDepartment of Pathology, University of Illinois at Chicago, 840 S. Wood St., Room 130 CSN, MC 847, Chicago, IL 60612, USA
DNA/RNA
DUSP10 mRNA transcript variants.
Description
The DUSP10 gene consists of 5 exons and 4 introns spanning 40 kb.
Transcription
There are three mRNA transcript variants for DUSP10 and two protein isoforms. Variant 1 is the full length protein, isoform a. Variants 2 and 3 have different 5 mRNA transcripts, but the same start site in exon 3 and are missing the N-terminus. Variants 2 and 3 only contain the C-terminal catalytic domain and code for isoform b.
The ATG site is on Exon 2.
DUSP10 Variant 1 (isoform a), NM_007207.3.
DUSP10 Variant 2 (isoform b), NM_144728.1.
DUSP10 Variant 3 (isoform b), NM_144729.1.
The ATG site is on Exon 2.
DUSP10 Variant 1 (isoform a), NM_007207.3.
DUSP10 Variant 2 (isoform b), NM_144728.1.
DUSP10 Variant 3 (isoform b), NM_144729.1.
Proteins
Note
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
DUSP10 gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK.
DUSP10 gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK.
Description
DUSP10 gene is translated into two different protein products. Transcript variant 1 codes for the full-length DUSP10 isoform a (NP_009138.1) of 482 amino acids and a molecular weight of 52 kDa. Transcript variants 2 and 3 encode for a shorter protein, DUSP10 isoform b (NP_653329.1), that is 140 amino acids in length.
Expression
DUSP10 mRNA is widely expressed in liver, skeletal muscle, retina, macrophages, colon, fetal heart, spleen, infant brain, pregnant uterus, prostate epithelium and ovarian tumors.
DUSP10 mRNA is inducible by oxidative stress via JNK and ATF activation.
DUSP10 mRNA is inducible by oxidative stress via JNK and ATF activation.
Localisation
DUSP10 is present in both the cytoplasm and nucleus of the cell.
Function
DUSP10 is a MAP kinase phosphatase with substrate specificy for jun N-terminal kinase (JNK) and p38.
Homology
The DUSP10 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish.
Mutations
Note
There are no characterized mutations in DUSP10.
Implicated in
Entity name
Prostate cancer
Note
To date, DUSP10 levels or mutation have not been associated with any disease. However, DUSP10 mRNA levels were lower in prostate cell lines derived from malignant tumor than from cells derived from normal prostate tissue (Nonn et al., 2006). Additionally, DUSP10 mRNA levels are inducible in prostate cells by treatment with 1,25-dihydoxyvitamin D, curcumin, reseveratrol and gingerol (Nonn et al., 2006; Nonn et al., 2007).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16806267 | 2006 | Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. | Jeong DG et al |
| 11060451 | 2000 | Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. | Masuda K et al |
| 17151092 | 2007 | Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. | Nonn L et al |
| 16618780 | 2006 | Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. | Nonn L et al |
| 10391943 | 1999 | Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. | Tanoue T et al |
| 17681939 | 2007 | Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress. | Teng CH et al |
| 10597297 | 1999 | MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases. | Theodosiou A et al |
| 15306813 | 2004 | Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. | Zhang Y et al |
Other Information
Locus ID:
NCBI: 11221
MIM: 608867
HGNC: 3065
Ensembl: ENSG00000143507
Variants:
dbSNP: 11221
ClinVar: 11221
TCGA: ENSG00000143507
COSMIC: DUSP10
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143507 | ENST00000366899 | Q9Y6W6 |
| ENSG00000143507 | ENST00000468085 | A0A0B4J2F5 |
| ENSG00000143507 | ENST00000477026 | A0A0B4J2F5 |
| ENSG00000143507 | ENST00000494642 | A0A0B4J2F5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37387540 | 2023 | DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma. | 0 |
| 37387540 | 2023 | DUSP10 is a novel immune-related biomarker connected with survival and cellular proliferation in lower-grade glioma. | 0 |
| 35488020 | 2022 | MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma. | 8 |
| 35488020 | 2022 | MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma. | 8 |
| 33232789 | 2021 | SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer. | 11 |
| 34782469 | 2021 | De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes. | 3 |
| 33232789 | 2021 | SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer. | 11 |
| 34782469 | 2021 | De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes. | 3 |
| 32843541 | 2020 | An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. | 9 |
| 32843541 | 2020 | An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. | 9 |
| 30333178 | 2019 | DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling. | 15 |
| 31122150 | 2019 | Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells. | 2 |
| 31202710 | 2019 | The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis. | 7 |
| 31483681 | 2019 | Role of dual-specificity protein phosphatase DUSP10/MKP-5 in pulmonary fibrosis. | 19 |
| 30333178 | 2019 | DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling. | 15 |
Citation
Larisa Nonn
DUSP10 (dual specificity phosphatase 10)
Atlas Genet Cytogenet Oncol Haematol. 2010-05-01
Online version: http://atlasgeneticsoncology.org/gene/49913/dusp10
