APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2)
2007-12-01 Affiliation
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55198
MIM: 606231
HGNC: 18242
Ensembl: ENSG00000136044
Variants:
dbSNP: 55198
ClinVar: 55198
TCGA: ENSG00000136044
COSMIC: APPL2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33122440 | 2020 | The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells. | 15 |
| 33122440 | 2020 | The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells. | 15 |
| 30218350 | 2018 | Overexpressed in colorectal carcinoma gene (OCC-1) upregulation and APPL2 gene downregulation in breast cancer specimens. | 2 |
| 30218350 | 2018 | Overexpressed in colorectal carcinoma gene (OCC-1) upregulation and APPL2 gene downregulation in breast cancer specimens. | 2 |
| 27986894 | 2017 | Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway. | 9 |
| 27986894 | 2017 | Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway. | 9 |
| 26583432 | 2016 | APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain. | 11 |
| 26583432 | 2016 | APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain. | 11 |
| 24763056 | 2014 | APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. | 13 |
| 24763056 | 2014 | APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. | 13 |
| 22989406 | 2013 | Multifunctional protein APPL2 contributes to survival of human glioma cells. | 11 |
| 23891720 | 2013 | Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates β-catenin dependent transcriptional events. | 1 |
| 23977033 | 2013 | Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease. | 8 |
| 22989406 | 2013 | Multifunctional protein APPL2 contributes to survival of human glioma cells. | 11 |
| 23891720 | 2013 | Mutually exclusive binding of APPL(PH) to BAR domain and Reptin regulates β-catenin dependent transcriptional events. | 1 |
Citation
Dessen P
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49917/appl2
