GRAP2 (GRB2 related adaptor protein 2)

2007-12-01  

Identity

HGNC
GRAP2
LOCATION
22q13.1
LOCUSID
9402
ALIAS
GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9402
MIM: 604518
HGNC: 4563
Ensembl: ENSG00000100351

Variants:

dbSNP: 9402
ClinVar: 9402
TCGA: ENSG00000100351
COSMIC: GRAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100351ENST00000344138O75791
ENSG00000100351ENST00000344138Q6FI14
ENSG00000100351ENST00000407075O75791
ENSG00000100351ENST00000407075Q6FI14
ENSG00000100351ENST00000420971B1AH86

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
T cell receptor signaling pathwayKEGGko04660
T cell receptor signaling pathwayKEGGhsa04660
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Costimulation by the CD28 familyREACTOMER-HSA-388841
CD28 co-stimulationREACTOMER-HSA-389356
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
FCERI mediated Ca+2 mobilizationREACTOMER-HSA-2871809
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
279279892017Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.6
282890742017T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.23
279279892017Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.6
282890742017T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.23
254521062015Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.7
256362002015GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.12
254521062015Modulation of TCR responsiveness by the Grb2-family adaptor, Gads.7
256362002015GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.12
233998932013Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.4
233998932013Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia.4
200794312010The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway.8
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
211795102010Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.6
200794312010The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway.8

Citation

Dessen P

GRAP2 (GRB2 related adaptor protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49932/deep-insight-explorer/haematological-explorer/tumors-explorer/