Identity
HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
JC310,MIP1,SIN1,SIN1b,SIN1g
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79109
MIM: 610558
HGNC: 18752
Ensembl: ENSG00000119487
Variants:
dbSNP: 79109
ClinVar: 79109
TCGA: ENSG00000119487
COSMIC: MAPKAP1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37877351 | 2023 | Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2. | 2 |
| 37877351 | 2023 | Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2. | 2 |
| 35926713 | 2022 | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. | 12 |
| 35926713 | 2022 | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. | 12 |
| 34380736 | 2021 | RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. | 15 |
| 34380736 | 2021 | RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. | 15 |
| 31773361 | 2020 | Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant. | 3 |
| 32088212 | 2020 | Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades. | 5 |
| 32873626 | 2020 | G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity. | 4 |
| 31773361 | 2020 | Genetic Predisposition to Glioma Mediated by a MAPKAP1 Enhancer Variant. | 3 |
| 32088212 | 2020 | Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades. | 5 |
| 32873626 | 2020 | G-Protein-Coupled Estrogen Receptor 1 Promotes Gender Disparities in Hepatocellular Carcinoma via Modulation of SIN1 and mTOR Complex 2 Activity. | 4 |
| 30217824 | 2018 | c-Jun N-terminal kinase (JNK)-mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis. | 5 |
| 30571167 | 2018 | Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. | 9 |
| 30217824 | 2018 | c-Jun N-terminal kinase (JNK)-mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis. | 5 |
Citation
Dessen P
MAPKAP1 (MAPK associated protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49954/mapkap1
