ADORA2A (adenosine A2a receptor)

2007-12-01  

Identity

HGNC
ADORA2A
LOCATION
22q11.23
LOCUSID
135
ALIAS
A2aR,ADORA2,RDC8

Other Information

Locus ID:

NCBI: 135
MIM: 102776
HGNC: 263
Ensembl: ENSG00000128271

Variants:

dbSNP: 135
ClinVar: 135
TCGA: ENSG00000128271
COSMIC: ADORA2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128271ENST00000337539P29274
ENSG00000128271ENST00000337539X5DNB4
ENSG00000128271ENST00000424232C9JFS2
ENSG00000128271ENST00000436735C9J3T2
ENSG00000128271ENST00000439591C9J0Z4
ENSG00000128271ENST00000444262C9JQD8
ENSG00000128271ENST00000472248S4R429
ENSG00000128271ENST00000486108S4R2Z8
ENSG00000128271ENST00000496258S4R3A7
ENSG00000128271ENST00000610595P29274
ENSG00000128271ENST00000610595X5DNB4
ENSG00000128271ENST00000611543P29274
ENSG00000128271ENST00000611543X5DNB4
ENSG00000128271ENST00000618076P29274
ENSG00000128271ENST00000618076X5DNB4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Parkinson's diseaseKEGGhsa05012
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Metabolism of proteinsREACTOMER-HSA-392499
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Activation of TRKA receptorsREACTOMER-HSA-187015
NGF-independant TRKA activationREACTOMER-HSA-187024
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
thymus
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD18539621
PA446827Hematologic NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27399166
PA446975Neurotoxicity SyndromesDiseaseVariantAnnotationassociatedPD27399166
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD
PA448710caffeineChemicalClinicalAnnotationassociatedPD12825092, 17329997, 17616786, 18305461, 20520601, 22012471
PA450428methotrexateChemicalClinicalAnnotation, VariantAnnotationassociatedPD18539621, 27399166

References

Pubmed IDYearTitleCitations
384419672024CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.1
385227622024Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.0
386421312024A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.1
387319622024Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer.0
388923242024Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.0
384419672024CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.1
385227622024Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition.0
386421312024A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis.1
387319622024Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer.0
388923242024Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.0
346513892023Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma.1
360533862023Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson's disease.2
366348662023Striatopallidal adenosine A(2A) receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility.6
366379882023Comparative Study of Receptor-, Receptor State-, and Membrane-Dependent Cholesterol Binding Sites in A(2A) and A(1) Adenosine Receptors Using Coarse-Grained Molecular Dynamics Simulations.2
368350782023Increased Density of Endogenous Adenosine A(2A) Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients.1

Citation

Dessen P

ADORA2A (adenosine A2a receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49956/gene-explorer/css/case-report-explorer/