Identity
HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
CANP10,NIDDM1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11132
MIM: 605286
HGNC: 1477
Ensembl: ENSG00000142330
Variants:
dbSNP: 11132
ClinVar: 11132
TCGA: ENSG00000142330
COSMIC: CAPN10
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Extracellular matrix organization | REACTOME | R-HSA-1474244 |
| Degradation of the extracellular matrix | REACTOME | R-HSA-1474228 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 19752882 | |
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PD | 25327507 | |
| PA450395 | metformin | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 25327507 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PD | 19752882 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38166877 | 2024 | Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis. | 2 |
| 38166877 | 2024 | Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis. | 2 |
| 37823570 | 2023 | Identification of DNA methylation of CAPN10 gene changes in the patients with type 2 diabetes mellitus as a predictive biomarker instead of HbA1c, random blood sugar, lipid profile, kidney function test, and some risk factors. | 0 |
| 38139275 | 2023 | Dysregulated miRNA-375, IL-17, TGF-β, and Microminerals Are Associated with Calpain-10 SNP 19 in Diabetic Patients: Correlation with Diabetic Nephropathy Stages. | 1 |
| 38213994 | 2023 | Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women. | 2 |
| 37823570 | 2023 | Identification of DNA methylation of CAPN10 gene changes in the patients with type 2 diabetes mellitus as a predictive biomarker instead of HbA1c, random blood sugar, lipid profile, kidney function test, and some risk factors. | 0 |
| 38139275 | 2023 | Dysregulated miRNA-375, IL-17, TGF-β, and Microminerals Are Associated with Calpain-10 SNP 19 in Diabetic Patients: Correlation with Diabetic Nephropathy Stages. | 1 |
| 38213994 | 2023 | Molecular role of non-exonic variants in CALPAIN 10 gene in polycystic ovarian syndrome in Saudi women. | 2 |
| 32236617 | 2020 | Clinical significance of sHER2‑ECD and calpain‑10 expression in tumor tissues of patients with breast cancer. | 1 |
| 32236617 | 2020 | Clinical significance of sHER2‑ECD and calpain‑10 expression in tumor tissues of patients with breast cancer. | 1 |
| 31292430 | 2019 | The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus. | 5 |
| 31460838 | 2019 | GSTT1, Calpain 10 SNP 19 and indices of glycaemia in type 2 diabetes. | 1 |
| 31292430 | 2019 | The Association Between the rs2975760 and rs3792267 Single Nucleotide Polymorphisms of Calpain 10 (CAPN10) and Gestational Diabetes Mellitus. | 5 |
| 31460838 | 2019 | GSTT1, Calpain 10 SNP 19 and indices of glycaemia in type 2 diabetes. | 1 |
| 29506634 | 2018 | Association analysis of calpain 10 gene variants/haplotypes with gestational diabetes mellitus among Mexican women. | 5 |
Citation
Dessen P
CAPN10 (calpain 10)
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/49989/capn10
