SLC39A4 (solute carrier family 39 member 4)

2007-02-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
AEZ,AWMS2,ZIP4

Other Information

Locus ID:

NCBI: 55630
MIM: 607059
HGNC: 17129
Ensembl: ENSG00000147804

Variants:

dbSNP: 55630
ClinVar: 55630
TCGA: ENSG00000147804
COSMIC: SLC39A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147804ENST00000276833Q6P5W5
ENSG00000147804ENST00000301305Q6P5W5
ENSG00000147804ENST00000526658E9PQ16

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

References

Pubmed IDYearTitleCitations
382175402024ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.0
382175402024ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis.0
377002772023GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data.0
377002772023GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data.0
364739152022The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo.0
364739152022The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo.0
336316102021Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.17
336316102021Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.17
317119242020ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells.51
319145892020Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.21
319791552020Elucidating the H(+) Coupled Zn(2+) Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.20
319870332020Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature.6
317119242020ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells.51
319145892020Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.21
319791552020Elucidating the H(+) Coupled Zn(2+) Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.20

Citation

Dessen P

SLC39A4 (solute carrier family 39 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50007/slc39a4