GLCE (glucuronic acid epimerase)

2007-02-01  

Identity

HGNC
LOCATION
15q23
LOCUSID
ALIAS
HSEPI
FUSION GENES

Other Information

Locus ID:

NCBI: 26035
MIM: 612134
HGNC: 17855
Ensembl: ENSG00000138604

Variants:

dbSNP: 26035
ClinVar: 26035
TCGA: ENSG00000138604
COSMIC: GLCE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138604ENST00000261858O94923
ENSG00000138604ENST00000559420H0YNP1

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGko00534
Glycosaminoglycan biosynthesis - heparan sulfate / heparinKEGGhsa00534
Metabolic pathwaysKEGGhsa01100
Glycosaminoglycan biosynthesis, heparan sulfate backboneKEGGhsa_M00059
Glycosaminoglycan biosynthesis, heparan sulfate backboneKEGGM00059
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG biosynthesisREACTOMER-HSA-2022928

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
342332932021Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1.7
342332932021Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1.7
323043242020Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase.3
323043242020Elucidating the unusual reaction kinetics of D-glucuronyl C5-epimerase.3
308724812019Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.12
318348782019Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.9
308724812019Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.12
318348782019Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy.9
287348942017GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.8
287348942017GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.8
275111242016Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.6
276997672016Glucuronic Acid Epimerase (GLCE) Variant rs3865014 (A>G) Is Associated with BMI, Blood Hemoglobin, Hypertension, and Cerebrovascular Events, the TAMRISK Study.2
275111242016Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.6
276997672016Glucuronic Acid Epimerase (GLCE) Variant rs3865014 (A>G) Is Associated with BMI, Blood Hemoglobin, Hypertension, and Cerebrovascular Events, the TAMRISK Study.2
255947472015C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains.11

Citation

Dessen P

GLCE (glucuronic acid epimerase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50024/glce