DBF4 (DBF4 zinc finger)

2008-03-01  

Identity

HGNC
DBF4
LOCATION
7q21.12
LOCUSID
10926
ALIAS
ASK,CHIF,DBF4A,ZDBF1

Other Information

Locus ID:

NCBI: 10926
MIM: 604281
HGNC: 17364
Ensembl: ENSG00000006634

Variants:

dbSNP: 10926
ClinVar: 10926
TCGA: ENSG00000006634
COSMIC: DBF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006634ENST00000265728Q9UBU7
ENSG00000006634ENST00000413643Q9UBU7
ENSG00000006634ENST00000430279B4DXK0
ENSG00000006634ENST00000431138F8WF77

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
DNA ReplicationREACTOMER-HSA-69306

References

Pubmed IDYearTitleCitations
387246062024The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma.0
388650902024DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.0
387246062024The prognostic significance and potential mechanism of DBF4 zinc finger in hepatocellular carcinoma.0
388650902024DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.0
374970042023DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.2
374970042023DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.2
349753312022Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma.20
349753312022Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma.20
333779732021Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis.0
333779732021Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis.0
301574712018DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.12
301574712018DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling.12
284488022017DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.12
292090462017Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.13
284488022017DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.12

Citation

Dessen P

DBF4 (DBF4 zinc finger)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50062