PANX2 (pannexin 2)

2008-03-01  

Identity

HGNC
PANX2
LOCATION
22q13.33
LOCUSID
56666
ALIAS
PX2,hPANX2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56666
MIM: 608421
HGNC: 8600
Ensembl: ENSG00000073150

Variants:

dbSNP: 56666
ClinVar: 56666
TCGA: ENSG00000073150
COSMIC: PANX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073150ENST00000159647Q96RD6
ENSG00000073150ENST00000395842Q96RD6
ENSG00000073150ENST00000402472F8W8Y4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Transmission across Electrical SynapsesREACTOMER-HSA-112307
Electric Transmission Across Gap JunctionsREACTOMER-HSA-112303

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368690382023Cryo-EM structure of human heptameric pannexin 2 channel.3
369732892023Structural and functional analysis of human pannexin 2 channel.3
368690382023Cryo-EM structure of human heptameric pannexin 2 channel.3
369732892023Structural and functional analysis of human pannexin 2 channel.3
339133722021PANX2 and brain lower grade glioma genesis: A bioinformatic analysis.7
339133722021PANX2 and brain lower grade glioma genesis: A bioinformatic analysis.7
327702092020Pannexin-2, a novel mitochondrial-associated membrane protein, may become the new strategy to treat and prevent neurological disorders.3
330036472020The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2.15
327702092020Pannexin-2, a novel mitochondrial-associated membrane protein, may become the new strategy to treat and prevent neurological disorders.3
330036472020The Role of miR-342 in Vascular Health. Study in Subclinical Cardiovascular Disease in Mononuclear Cells, Plasma, Inflammatory Cytokines and PANX2.15
293579452018Human stem cells express pannexins.4
299321122018N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1.9
293579452018Human stem cells express pannexins.4
299321122018N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1.9
280362892017Expression of pannexin 1 and 2 in cortical lesions from intractable epilepsy patients with focal cortical dysplasia.13

Citation

Dessen P

PANX2 (pannexin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50085/css/template-card.css