LPA (lipoprotein(a))

2008-05-01  

Identity

HGNC
LPA
LOCATION
6q25.3
LOCUSID
4018
ALIAS
AK38,APOA,LP

Other Information

Locus ID:

NCBI: 4018
MIM: 152200
HGNC: 6667
Ensembl: ENSG00000198670

Variants:

dbSNP: 4018
ClinVar: 4018
TCGA: ENSG00000198670
COSMIC: LPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198670ENST00000316300P08519
ENSG00000198670ENST00000447678P08519
ENSG00000198670ENST00000614786A0A087WWY0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociatedPD22331829, 23903772, 25350695, 27045730, 29703846
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD22331829, 23903772, 25350695, 27045730, 29703846

References

Pubmed IDYearTitleCitations
373928382024Dysregulation of the LPC-ATX-LPA axis in autoimmune hepatitis is associated with monocyte activation.1
375530642024Association Between Lipoprotein (a) and Risk of Atrial Fibrillation: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.5
376506932024Lipoprotein(a) and calcific aortic valve disease: current evidence and future directions.0
377776992024Lipoprotein(a) is associated with recurrent cardiovascular events in patients with coronary artery disease and prediabetes or diabetes.4
379374632024Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease.1
379387562024Lipoprotein(a), platelet function and cardiovascular disease.3
379977922024The 10 essential questions regarding lipoprotein(a).0
380657152024Lipoprotein(a) levels and carotid intima-media thickness in children: A 20-year follow-up study.1
381012702024The association of lipoprotein (a) with coronary artery calcification: A systematic review and meta-analysis.0
382390892024Association of Lipoprotein(a) with arterial stiffness: A Mendelian randomization study.0
382541712024Predictive value of lipoprotein(a) for left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients with low CHA(2)DS(2)-VASc scores: a cross-sectional study.1
382558102024Haplotype of the Lipoprotein(a) Gene Variants rs10455872 and rs3798220 Is Associated with Parameters of Coagulation, Fibrinolysis, and Inflammation in Patients after Myocardial Infarction and Highly Elevated Lipoprotein(a) Values.0
382695882024Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.1
383019172024Association between lipoprotein (a) and risk of heart failure: A systematic review and meta-analysis of Mendelian randomization studies.0
387221182024Confounding Factors Responsible for Elevated Lp(a) Levels in Patients with Coronary Artery Disease.0

Citation

Dessen P

LPA (lipoprotein(a))

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50112