DPYSL5 (dihydropyrimidinase like 5)

2008-05-01  

Identity

HGNC
LOCATION
2p23.3
LOCUSID
ALIAS
CRAM,CRMP-5,CRMP5,CV2,Ulip6
FUSION GENES

Other Information

Locus ID:

NCBI: 56896
MIM: 608383
HGNC: 20637
Ensembl: ENSG00000157851

Variants:

dbSNP: 56896
ClinVar: 56896
TCGA: ENSG00000157851
COSMIC: DPYSL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157851ENST00000288699Q9BPU6
ENSG00000157851ENST00000401478Q9BPU6
ENSG00000157851ENST00000431402E7EWB4
ENSG00000157851ENST00000434719E7ESV0
ENSG00000157851ENST00000450961E9PHT0
ENSG00000157851ENST00000614712Q9BPU6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
CRMPs in Sema3A signalingREACTOMER-HSA-399956

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
338941262021Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.14
338941262021Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.14
314039412019miR-214-5p inhibits human prostate cancer proliferation and migration through regulating CRMP5.18
314039412019miR-214-5p inhibits human prostate cancer proliferation and migration through regulating CRMP5.18
283749152017DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.5
283749152017DRP5 is involved in cancer cell growth and predicts poor prognosis in human osteosarcoma.5
261228472015CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.22
261228472015CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.22
243242682014Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.14
246955782014High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.3
243242682014Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites.14
246955782014High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma.3
232989462013Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.8
233737492013Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5.16
232989462013Identification of a new CRMP5 isoform present in the nucleus of cancer cells and enhancing their proliferation.8

Citation

Dessen P

DPYSL5 (dihydropyrimidinase like 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50119/dpysl5