KRT16 (keratin 16)

2008-05-01 Affiliation

Identity

HGNC

KRT16

LOCATION

17q21.2

LOCUSID

3868

ALIAS

CK16,FNEPPK,K16,K1CP,KRT16A,NEPPK,PC1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3868
MIM: 148067
HGNC: 6423
Ensembl: ENSG00000186832

Variants:

dbSNP: 3868
ClinVar: 3868
TCGA: ENSG00000186832
COSMIC: KRT16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186832	ENST00000301653	P08779
ENSG00000186832	ENST00000590990	K7ENV3
ENSG00000186832	ENST00000593067	K7ENW6

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Keratinization	REACTOME	R-HSA-6805567

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38892279	2024	GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples.	0
38892279	2024	GLI Transcriptional Targets S100A7 and KRT16 Show Upregulated Expression Patterns in Epidermis Overlying the Tumor Mass in Melanoma Samples.	0
36149327	2023	A novel KRT16 frameshift variant causing pachyonychia congenita by re-initiation of translation.	0
37315823	2023	Targeting the KRT16-vimentin axis for metastasis in lung cancer.	1
36149327	2023	A novel KRT16 frameshift variant causing pachyonychia congenita by re-initiation of translation.	0
37315823	2023	Targeting the KRT16-vimentin axis for metastasis in lung cancer.	1
35037835	2022	BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression.	2
35037835	2022	BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression.	2
30782177	2019	A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway.	49
30859684	2019	A KRT16 mutation in the first Chinese pedigree with Pachyonychia congenita and review of the literatures.	2
30942529	2019	Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway.	8
31337972	2019	TFAP2A Induced KRT16 as an Oncogene in Lung Adenocarcinoma via EMT.	30
30782177	2019	A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway.	49
30859684	2019	A KRT16 mutation in the first Chinese pedigree with Pachyonychia congenita and review of the literatures.	2
30942529	2019	Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway.	8

Citation

Dessen P

KRT16 (keratin 16)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50129