Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7498
MIM: 607633
HGNC: 12805
Ensembl: ENSG00000158125
Variants:
dbSNP: 7498
ClinVar: 7498
TCGA: ENSG00000158125
COSMIC: XDH
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158125 | ENST00000379416 | P47989 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165958521 | febuxostat | Chemical | Pathway, VariantAnnotation | associated | PD | 24915143, 27798726 | |
| PA444318 | Gout | Disease | VariantAnnotation | associated | PD | 27798726 | |
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 23315321 | |
| PA448320 | allopurinol | Chemical | Pathway, VariantAnnotation | associated | PD | 24915143, 27798726 | |
| PA449301 | didanosine | Chemical | ClinicalAnnotation | associated | PD | 23315321 | |
| PA451647 | theophylline | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36739755 | 2023 | The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke. | 8 |
| 37258622 | 2023 | Overnight changes in uric acid, xanthine oxidoreductase and oxidative stress levels and their relationships with sleep-disordered breathing in patients with coronary artery disease. | 2 |
| 37415141 | 2023 | Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure. | 1 |
| 37713777 | 2023 | Natural mutations of human XDH promote the nitrite (NO(2)(-))-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? | 0 |
| 36739755 | 2023 | The clinical value of serum xanthine oxidase levels in patients with acute ischemic stroke. | 8 |
| 37258622 | 2023 | Overnight changes in uric acid, xanthine oxidoreductase and oxidative stress levels and their relationships with sleep-disordered breathing in patients with coronary artery disease. | 2 |
| 37415141 | 2023 | Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure. | 1 |
| 37713777 | 2023 | Natural mutations of human XDH promote the nitrite (NO(2)(-))-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health? | 0 |
| 34619144 | 2022 | Association of Plasma Xanthine Oxidoreductase with Arterial Stiffness in Type 2 Diabetes with Liver Dysfunction. | 2 |
| 35154100 | 2022 | Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. | 5 |
| 35164526 | 2022 | Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension. | 4 |
| 35717455 | 2022 | Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees. | 3 |
| 35916133 | 2022 | XDH genotypes through gene-gene interactions with NUDT15 affect azathioprine-induced leukopenia in Chinese patients. | 0 |
| 34619144 | 2022 | Association of Plasma Xanthine Oxidoreductase with Arterial Stiffness in Type 2 Diabetes with Liver Dysfunction. | 2 |
| 35154100 | 2022 | Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. | 5 |
Citation
Dessen P
XDH (xanthine dehydrogenase)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50157/xdh
