Identity
HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
PRAP,RA70,SAPS,SCAP2,SKAP-HOM,SKAP55R
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8935
MIM: 605215
HGNC: 15687
Ensembl: ENSG00000005020
Variants:
dbSNP: 8935
ClinVar: 8935
TCGA: ENSG00000005020
COSMIC: SKAP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000005020 | ENST00000345317 | O75563 |
| ENSG00000005020 | ENST00000432747 | C9JQ17 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell-Cell communication | REACTOME | R-HSA-1500931 |
| Signal regulatory protein (SIRP) family interactions | REACTOME | R-HSA-391160 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38487529 | 2024 | SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function. | 0 |
| 38487529 | 2024 | SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function. | 0 |
| 36126383 | 2022 | SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway. | 4 |
| 36126383 | 2022 | SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway. | 4 |
| 33203694 | 2021 | SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients. | 4 |
| 34172489 | 2021 | Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. | 4 |
| 34295339 | 2021 | The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. | 10 |
| 33203694 | 2021 | SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients. | 4 |
| 34172489 | 2021 | Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation. | 4 |
| 34295339 | 2021 | The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events. | 10 |
| 26577701 | 2016 | SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression. | 22 |
| 26577701 | 2016 | SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression. | 22 |
| 25862907 | 2015 | Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer. | 12 |
| 25862907 | 2015 | Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer. | 12 |
| 23161539 | 2013 | The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins. | 11 |
Citation
Dessen P
SKAP2 (src kinase associated phosphoprotein 2)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50165/skap2
