SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)

2008-07-01  

Identity

HGNC
SUPT16H
LOCATION
14q11.2
LOCUSID
11198
ALIAS
CDC68,FACTP140,SPT16,SPT16/CDC68
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11198
MIM: 605012
HGNC: 11465
Ensembl: ENSG00000092201

Variants:

dbSNP: 11198
ClinVar: 11198
TCGA: ENSG00000092201
COSMIC: SUPT16H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092201ENST00000216297Q9Y5B9
ENSG00000092201ENST00000555943G3V2X0
ENSG00000092201ENST00000556309G3V5A4
ENSG00000092201ENST00000557652G3V401

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
362557382023The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival.5
367693602023Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells.1
368016132023Structural basis for H2A-H2B recognitions by human Spt16.1
362557382023The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival.5
367693602023Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells.1
368016132023Structural basis for H2A-H2B recognitions by human Spt16.1
359048162022FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling.5
365773792022Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes.5
359048162022FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signaling.5
365773792022Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes.5
335264532021Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription.4
335264532021Proteasomal Regulation of Mammalian SPT16 in Controlling Transcription.4
317751572020FACT caught in the act of manipulating the nucleosome.96
318231552020Neurodevelopmental phenotype associated with CHD8-SUPT16H duplication.4
319246972020De novo variants in SUPT16H cause neurodevelopmental disorders associated with corpus callosum abnormalities.6

Citation

Dessen P

SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50177/css/js/_common.js