Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 255738
MIM: 607786
HGNC: 20001
Ensembl: ENSG00000169174
Variants:
dbSNP: 255738
ClinVar: 255738
TCGA: ENSG00000169174
COSMIC: PCSK9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169174 | ENST00000302118 | Q8NBP7 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166114922 | lomitapide | Chemical | LabelAnnotation | associated | |||
| PA166114942 | familial hypercholesterolemia | Disease | DataAnnotation, Literature, MultilinkAnnotation | associated | 23788249 | ||
| PA227 | LDLR | Gene | DataAnnotation | associated | |||
| PA50 | APOB | Gene | DataAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37420045 | 2024 | Longitudinal variation of serum PCSK9 in ulcerative colitis: association with disease activity, T helper 1/2/17 cells, and clinical response of tumor necrosis factor inhibitor. | 0 |
| 37748207 | 2024 | Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications. | 0 |
| 37903942 | 2024 | GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal. | 1 |
| 38154546 | 2024 | PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction. | 2 |
| 38383373 | 2024 | Proteome-wide mendelian randomization investigates potential associations in heart failure and its etiology: emphasis on PCSK9. | 0 |
| 38402551 | 2024 | PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells. | 1 |
| 38532495 | 2024 | Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis. | 0 |
| 38538222 | 2024 | The Impact of PCSK9 Gene Polymorphisms on Ischemic Stroke: A Systematic Review and Meta-Analysis. | 0 |
| 38568054 | 2024 | Association between genetically proxied PCSK9 inhibition and systemic lupus erythematosus risk: A mendelian randomization study. | 0 |
| 38734541 | 2024 | Effect of the PCSK9 R46L genetic variant on plasma insulin and glucose levels, risk of diabetes mellitus and cardiovascular disease: A meta-analysis. | 0 |
| 38972879 | 2024 | Assessment of serum proprotein convertase subtilisin/kexin type 9 in pediatric sepsis syndrome. | 0 |
| 37420045 | 2024 | Longitudinal variation of serum PCSK9 in ulcerative colitis: association with disease activity, T helper 1/2/17 cells, and clinical response of tumor necrosis factor inhibitor. | 0 |
| 37748207 | 2024 | Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications. | 0 |
| 37903942 | 2024 | GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal. | 1 |
| 38154546 | 2024 | PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction. | 2 |
Citation
Dessen P
PCSK9 (proprotein convertase subtilisin/kexin type 9)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50178/pcsk9
