UPF1 (UPF1 RNA helicase and ATPase)

2008-07-01  

Identity

HGNC
UPF1
LOCATION
19p13.11
LOCUSID
5976
ALIAS
HUPF1,NORF1,RENT1,UTF,pNORF1,smg-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5976
MIM: 601430
HGNC: 9962
Ensembl: ENSG00000005007

Variants:

dbSNP: 5976
ClinVar: 5976
TCGA: ENSG00000005007
COSMIC: UPF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005007ENST00000262803Q92900
ENSG00000005007ENST00000262803A0A024R7L5
ENSG00000005007ENST00000599848Q92900
ENSG00000005007ENST00000599848A0A024R7L8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371204952024LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis.4
380131272024LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis.0
381679132024Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.0
382446882024Nonsense-mediated mRNA decay affects hyperactive root formation in oculo-facio-cardio-dental syndrome via up-frameshift protein 1.0
384122992024UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.0
386257942024UPF1 regulates mRNA stability by sensing poorly translated coding sequences.0
387098912024UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.0
371204952024LncRNA GAS5 regulated by FTO-mediated m6A demethylation promotes autophagic cell death in NSCLC by targeting UPF1/BRD4 axis.4
380131272024LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis.0
381679132024Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells.0
382446882024Nonsense-mediated mRNA decay affects hyperactive root formation in oculo-facio-cardio-dental syndrome via up-frameshift protein 1.0
384122992024UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.0
386257942024UPF1 regulates mRNA stability by sensing poorly translated coding sequences.0
387098912024UPF1 helicase orchestrates mutually exclusive interactions with the SMG6 endonuclease and UPF2.0
364561822023Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.6

Citation

Dessen P

UPF1 (UPF1 RNA helicase and ATPase)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50179