HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)

2008-07-01 Affiliation

Identity

HGNC

HLA-DRB3

LOCATION

6p21.3

LOCUSID

3125

ALIAS

DRB3,HLA-DPB1,HLA-DR1B,HLA-DR3B,HLA-DRB3*

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3125
MIM: 612735
HGNC: 4951

Variants:

dbSNP: 3125
ClinVar: 3125
COSMIC: HLA-DRB3

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Antigen processing and presentation	KEGG	ko04612
Hematopoietic cell lineage	KEGG	ko04640
Type I diabetes mellitus	KEGG	ko04940
Asthma	KEGG	ko05310
Autoimmune thyroid disease	KEGG	ko05320
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Antigen processing and presentation	KEGG	hsa04612
Hematopoietic cell lineage	KEGG	hsa04640
Type I diabetes mellitus	KEGG	hsa04940
Asthma	KEGG	hsa05310
Autoimmune thyroid disease	KEGG	hsa05320
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Viral myocarditis	KEGG	hsa05416
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Phosphorylation of CD3 and TCR zeta chains	REACTOME	R-HSA-202427
Translocation of ZAP-70 to Immunological synapse	REACTOME	R-HSA-202430
Generation of second messenger molecules	REACTOME	R-HSA-202433
Downstream TCR signaling	REACTOME	R-HSA-202424
Costimulation by the CD28 family	REACTOME	R-HSA-388841
PD-1 signaling	REACTOME	R-HSA-389948
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443297	Agranulocytosis	Disease	VariantAnnotation	associated	PD	11266078
PA447216	Schizophrenia	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	11266078
PA447264	heparin-induced thrombocytopenia	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	28688202
PA449061	clozapine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	11266078
PA449855	heparin	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	28688202

References

Pubmed ID	Year	Title	Citations
36286990	2023	Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology.	0
36286990	2023	Full genomic sequence of the HLA-DRB3*02:32 allele by Single Molecule Real-time Sequencing Technology.	0
33565267	2021	Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing.	0
33565267	2021	Characterization of the novel HLA-DRB3*03:49 allele by sequencing-based typing.	0
32462780	2020	Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing.	0
32462780	2020	Characterization of the novel HLA-DRB3*02:02:25 allele by sequencing-based typing.	0
28019029	2017	HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia.	6
28028136	2017	HLA-DRB115:01 and HLA-DRB302:02 in PLA2R-Related Membranous Nephropathy.	30
28019029	2017	HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia.	6
28028136	2017	HLA-DRB115:01 and HLA-DRB302:02 in PLA2R-Related Membranous Nephropathy.	30
26740600	2016	Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.	33
27181214	2016	HLA-A33-DR3 and A33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.	6
26740600	2016	Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.	33
27181214	2016	HLA-A33-DR3 and A33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.	6
26475924	2015	A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus.	9

Citation

Dessen P

HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50186