SOX17 (SRY-box transcription factor 17)

2008-07-01  

Identity

HGNC
SOX17
LOCATION
8q11.23
LOCUSID
64321
ALIAS
VUR3

Other Information

Locus ID:

NCBI: 64321
MIM: 610928
HGNC: 18122
Ensembl: ENSG00000164736

Variants:

dbSNP: 64321
ClinVar: 64321
TCGA: ENSG00000164736
COSMIC: SOX17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164736ENST00000297316Q9H6I2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384188752024SOX17 enables immune evasion of early colorectal adenomas and cancers.4
385032912024SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells.0
385187812024Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2.0
384188752024SOX17 enables immune evasion of early colorectal adenomas and cancers.4
385032912024SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells.0
385187812024Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2.0
369197842023SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner.4
375769702023The dynamic expression of SOX17 in germ cells from human female foetus and adult ovaries after specification.0
377370272023E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.3
369197842023SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner.4
375769702023The dynamic expression of SOX17 in germ cells from human female foetus and adult ovaries after specification.0
377370272023E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.3
351246962022SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer.8
353808772022The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17.14
353903092022Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.2

Citation

Dessen P

SOX17 (SRY-box transcription factor 17)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50199