ATRIP (ATR interacting protein)

2008-07-01  

Identity

HGNC
ATRIP
LOCATION
3p21.31
LOCUSID
84126
ALIAS
-

Other Information

Locus ID:

NCBI: 84126
MIM: 606605
HGNC: 33499
Ensembl: ENSG00000164053

Variants:

dbSNP: 84126
ClinVar: 84126
TCGA: ENSG00000164053
COSMIC: ATRIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164053ENST00000320211Q8WXE1
ENSG00000164053ENST00000320211A0A024R2U4
ENSG00000164053ENST00000346691Q8WXE1
ENSG00000164053ENST00000346691A0A024R307
ENSG00000164053ENST00000357105Q8WXE1
ENSG00000164053ENST00000412052Q8WXE1
ENSG00000164053ENST00000634384A0A0U1RQJ8
ENSG00000164053ENST00000635082A0A0U1RQR9
ENSG00000164053ENST00000635099A0A0U1RRM7
ENSG00000164053ENST00000635464A0A0U1RQW3
ENSG00000164053ENST00000639561A0A1W2PQ89

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Activation of ATR in response to replication stressREACTOMER-HSA-176187
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Fanconi Anemia PathwayREACTOMER-HSA-6783310
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369774122023Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank.1
369774122023Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank.1
331100582020ATRIP protects progenitor cells against DNA damage in vivo.4
331100582020ATRIP protects progenitor cells against DNA damage in vivo.4
268542342016ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.34
268542342016ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.34
249909652014SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway.35
249909652014SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway.35
233454342013Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.43
234542122013HIF1-regulated ATRIP expression is required for hypoxia induced ATR activation.6
240738512013Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1.0
233454342013Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.43
234542122013HIF1-regulated ATRIP expression is required for hypoxia induced ATR activation.6
240738512013Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1.0
231446222012Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome.46

Citation

Dessen P

ATRIP (ATR interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50207/atrip