Identity
HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CMD1FF,CMD2A,CMH7,RCM1,TNNC1,cTnI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7137
MIM: 191044
HGNC: 11947
Ensembl: ENSG00000129991
Variants:
dbSNP: 7137
ClinVar: 7137
TCGA: ENSG00000129991
COSMIC: TNNI3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA162375571 | ACTC1 | Gene | DataAnnotation | associated | |||
| PA231 | LMNA | Gene | DataAnnotation | associated | |||
| PA28707 | GLA | Gene | DataAnnotation | associated | |||
| PA31351 | MYBPC3 | Gene | DataAnnotation | associated | |||
| PA31374 | MYH7 | Gene | DataAnnotation | associated | |||
| PA31380 | MYL2 | Gene | DataAnnotation | associated | |||
| PA31381 | MYL3 | Gene | DataAnnotation | associated | |||
| PA33752 | PRKAG2 | Gene | DataAnnotation | associated | |||
| PA36638 | TNNT2 | Gene | DataAnnotation | associated | |||
| PA36690 | TPM1 | Gene | DataAnnotation | associated | |||
| PA443632 | Cardiomyopathy, Dilated | Disease | DataAnnotation | associated | |||
| PA443633 | Cardiomyopathy, Hypertrophic | Disease | DataAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38193576 | 2024 | Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy. | 0 |
| 38497452 | 2024 | Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy. | 0 |
| 38683127 | 2024 | Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS/ATG5 in ageing hearts. | 0 |
| 38924380 | 2024 | Homozygous TNNI3 frameshift variant in a consanguineous family with lethal infantile dilated cardiomyopathy. | 0 |
| 38193576 | 2024 | Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy. | 0 |
| 38497452 | 2024 | Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy. | 0 |
| 38683127 | 2024 | Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS/ATG5 in ageing hearts. | 0 |
| 38924380 | 2024 | Homozygous TNNI3 frameshift variant in a consanguineous family with lethal infantile dilated cardiomyopathy. | 0 |
| 36332898 | 2023 | Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure. | 4 |
| 36332898 | 2023 | Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure. | 4 |
| 34702775 | 2022 | N-terminal pro-brain natriuretic peptide is an independent predictor of mortality in patients with sepsis. | 2 |
| 34998858 | 2022 | The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients. | 6 |
| 35112971 | 2022 | Clinical implications of cardiac troponin-I in patients with hypertensive crisis visiting the emergency department. | 12 |
| 35149778 | 2022 | Role of a lower cutoff of high sensitivity troponin I in identification of early cardiac damage in non-severe patients with COVID-19. | 4 |
| 35351712 | 2022 | Association of serum cardiac troponin I and severity of coronary stenosis in patients with varied renal functions: a retrospective cohort study. | 0 |
Citation
Dessen P
TNNI3 (troponin I3, cardiac type)
Atlas Genet Cytogenet Oncol Haematol. 2008-07-01
Online version: http://atlasgeneticsoncology.org/gene/50254/tnni3
