SLC36A1 (solute carrier family 36 member 1)

2008-07-01  

Identity

HGNC
SLC36A1
LOCATION
5q33.1
LOCUSID
206358
ALIAS
Dct1,LYAAT1,PAT1,TRAMD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 206358
MIM: 606561
HGNC: 18761
Ensembl: ENSG00000123643

Variants:

dbSNP: 206358
ClinVar: 206358
TCGA: ENSG00000123643
COSMIC: SLC36A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123643ENST00000243389Q7Z2H8
ENSG00000123643ENST00000429484Q7Z2H8
ENSG00000123643ENST00000517628H0YB60
ENSG00000123643ENST00000517945E5RG64
ENSG00000123643ENST00000519829E5RI40
ENSG00000123643ENST00000520111E5RHG5
ENSG00000123643ENST00000520701Q7Z2H8
ENSG00000123643ENST00000521925E7EW39
ENSG00000123643ENST00000522185H0YBS2
ENSG00000123643ENST00000616007Q7Z2H8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Proton-coupled neutral amino acid transportersREACTOMER-HSA-428559

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
302531872019The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity.3
315557432019SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.20
302531872019The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity.3
315557432019SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.20
281179012017Glycosylation affects the stability and subcellular distribution of human PAT1 protein.3
286707362017Amino acids suppress the expression of PAT1 on lysosomes via inducing the cleavage of a targeting signal.0
281179012017Glycosylation affects the stability and subcellular distribution of human PAT1 protein.3
286707362017Amino acids suppress the expression of PAT1 on lysosomes via inducing the cleavage of a targeting signal.0
234887882013Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1).2
239620422013Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.5
234887882013Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1).2
239620422013Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro.5
225741972012Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.74
228534472012Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by Gly-X(aa) dipeptides.4
229757092012Estradiol inhibits the activity of proton-coupled amino acid transporter PAT1 expressed in Xenopus oocytes.1

Citation

Dessen P

SLC36A1 (solute carrier family 36 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50264