Identity
HGNC
LOCATION
7q36.3
LOCUSID
ALIAS
DJ4,DnaJ,HHDJ1,HSJ-2,HSJ2,LGMD1D,LGMD1E,LGMDD1,MRJ,MSJ-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10049
MIM: 611332
HGNC: 14888
Ensembl: ENSG00000105993
Variants:
dbSNP: 10049
ClinVar: 10049
TCGA: ENSG00000105993
COSMIC: DNAJB6
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cellular responses to stress | REACTOME | R-HSA-2262752 |
| Cellular response to heat stress | REACTOME | R-HSA-3371556 |
| Regulation of HSF1-mediated heat shock response | REACTOME | R-HSA-3371453 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37584547 | 2024 | MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression. | 0 |
| 38244155 | 2024 | Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription. | 0 |
| 37584547 | 2024 | MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression. | 0 |
| 38244155 | 2024 | Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription. | 0 |
| 37797698 | 2023 | The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation. | 3 |
| 37894814 | 2023 | miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy. | 4 |
| 38110916 | 2023 | The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. | 2 |
| 37797698 | 2023 | The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation. | 3 |
| 37894814 | 2023 | miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy. | 4 |
| 38110916 | 2023 | The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation. | 2 |
| 33557929 | 2021 | A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy. | 4 |
| 34390836 | 2021 | DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease. | 12 |
| 33557929 | 2021 | A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy. | 4 |
| 34390836 | 2021 | DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease. | 12 |
| 31701262 | 2020 | DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma. | 23 |
Citation
Dessen P
DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6)
Atlas Genet Cytogenet Oncol Haematol. 2008-08-01
Online version: http://atlasgeneticsoncology.org/gene/50288/dnajb6
