DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6)

2008-08-01  

Identity

HGNC
DNAJB6
LOCATION
7q36.3
LOCUSID
10049
ALIAS
DJ4,DnaJ,HHDJ1,HSJ-2,HSJ2,LGMD1D,LGMD1E,LGMDD1,MRJ,MSJ-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10049
MIM: 611332
HGNC: 14888
Ensembl: ENSG00000105993

Variants:

dbSNP: 10049
ClinVar: 10049
TCGA: ENSG00000105993
COSMIC: DNAJB6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105993ENST00000262177O75190
ENSG00000105993ENST00000412557C9JDX6
ENSG00000105993ENST00000417758C9J2C4
ENSG00000105993ENST00000429029O75190
ENSG00000105993ENST00000437030C9JB42
ENSG00000105993ENST00000439402C9JN01
ENSG00000105993ENST00000441291F8WCZ4
ENSG00000105993ENST00000441561C9J2P2
ENSG00000105993ENST00000443280E9PH18
ENSG00000105993ENST00000453383C9JDR7
ENSG00000105993ENST00000459889A0A0J9YX62
ENSG00000105993ENST00000634080A0A0J9YX62

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375845472024MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression.0
382441552024Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription.0
375845472024MUC1 promotes lymph node metastasis in esophageal squamous cell carcinoma by downregulating DNAJB6 expression.0
382441552024Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription.0
377976982023The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation.3
378948142023miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy.4
381109162023The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation.2
377976982023The C-terminal domain of the antiamyloid chaperone DNAJB6 binds to amyloid-β peptide fibrils and inhibits secondary nucleation.3
378948142023miR-632 Induces DNAJB6 Inhibition Stimulating Endothelial-to-Mesenchymal Transition and Fibrosis in Marfan Syndrome Aortopathy.4
381109162023The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation.2
335579292021A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.4
343908362021DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.12
335579292021A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy.4
343908362021DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkinson's disease.12
317012622020DNAJB6 Promotes Ferroptosis in Esophageal Squamous Cell Carcinoma.23

Citation

Dessen P

DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50288/img/logo-atlas-4.svg