EDN3 (endothelin 3)

2008-08-01  

Identity

HGNC
EDN3
LOCATION
20q13.32
LOCUSID
1908
ALIAS
ET-3,ET3,HSCR4,PPET3,WS4B

Other Information

Locus ID:

NCBI: 1908
MIM: 131242
HGNC: 3178
Ensembl: ENSG00000124205

Variants:

dbSNP: 1908
ClinVar: 1908
TCGA: ENSG00000124205
COSMIC: EDN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124205ENST00000311585P14138
ENSG00000124205ENST00000337938P14138
ENSG00000124205ENST00000371025Q4FAT2
ENSG00000124205ENST00000371028P14138
ENSG00000124205ENST00000395654P14138
ENSG00000124205ENST00000644821A0A2R8Y214

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
365421592023Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.1
365421592023Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer.1
335378322021miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells.3
335378322021miR‑27a‑3p regulates the inhibitory influence of endothelin 3 on the tumorigenesis of papillary thyroid cancer cells.3
315069272020Growth factor and receptor malfunctions associated with human genetic deafness.4
323155462020The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk and dynamic TIMI risk score in ST elevation acute myocardial infarction.2
325895902020Insights into Endothelin-3 and Multiple Sclerosis.3
315069272020Growth factor and receptor malfunctions associated with human genetic deafness.4
323155462020The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk and dynamic TIMI risk score in ST elevation acute myocardial infarction.2
325895902020Insights into Endothelin-3 and Multiple Sclerosis.3
311676512019Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients.1
311676512019Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients.1
288809272017SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.3
288809272017SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions.3
278632722016Genome-wide analysis of aberrant gene expression and methylation profiles reveals susceptibility genes and underlying mechanism of cervical cancer.11

Citation

Dessen P

EDN3 (endothelin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50297