NABP2 (nucleic acid binding protein 2)

2008-08-01  

Identity

HGNC
NABP2
LOCATION
12q13.3
LOCUSID
79035
ALIAS
OBFC2B,SOSS-B1,SSB1,hSSB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79035
MIM: 612104
HGNC: 28412
Ensembl: ENSG00000139579

Variants:

dbSNP: 79035
ClinVar: 79035
TCGA: ENSG00000139579
COSMIC: NABP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139579ENST00000267023Q9BQ15
ENSG00000139579ENST00000267023A0A024RB89
ENSG00000139579ENST00000341463Q9BQ15
ENSG00000139579ENST00000341463A0A024RB89
ENSG00000139579ENST00000380198Q9BQ15
ENSG00000139579ENST00000380198A0A024RB89
ENSG00000139579ENST00000399713C9JMP5
ENSG00000139579ENST00000447747C9JT95

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368113812023hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.5
368113812023hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.5
342707062021Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.1
344648982021Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces.5
342707062021Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5.1
344648982021Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces.5
285062942017hSSB1 associates with and promotes stability of the BLM helicase.5
285062942017hSSB1 associates with and promotes stability of the BLM helicase.5
272732182016hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.18
273872852016A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.15
272732182016hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.18
273872852016A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.15
262612122015hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.19
262612122015hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.19
247534082014Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.33

Citation

Dessen P

NABP2 (nucleic acid binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50299/css/lib/js/lib/jquery-3.5.1.min.js