WSB1 (WD repeat and SOCS box containing 1)

2008-09-01  

Identity

HGNC
WSB1
LOCATION
17q11.1
LOCUSID
26118
ALIAS
SWIP1,WSB-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26118
MIM: 610091
HGNC: 19221
Ensembl: ENSG00000109046

Variants:

dbSNP: 26118
ClinVar: 26118
TCGA: ENSG00000109046
COSMIC: WSB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109046ENST00000262394Q9Y6I7
ENSG00000109046ENST00000262394A0A024QZ51
ENSG00000109046ENST00000348811Q9Y6I7
ENSG00000109046ENST00000348811A0A024QZ36
ENSG00000109046ENST00000427287B4DGB8
ENSG00000109046ENST00000579733J3KRG6
ENSG00000109046ENST00000581185B4DTL1
ENSG00000109046ENST00000581440J3KT03
ENSG00000109046ENST00000582208J3QLM8
ENSG00000109046ENST00000583193J3KSQ3
ENSG00000109046ENST00000583742J3KS88
ENSG00000109046ENST00000584114J3KTB3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384522062024WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.0
384522062024WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.0
376286092023WSB1 Involvement in Prostate Cancer Progression.0
376286092023WSB1 Involvement in Prostate Cancer Progression.0
336927952021WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides.1
336927952021WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides.1
330999292020High expression of WSB1 is associated with poor prognosis in hepatocellular carcinoma and affects epithelial-mesenchymal transition.2
330999292020High expression of WSB1 is associated with poor prognosis in hepatocellular carcinoma and affects epithelial-mesenchymal transition.2
295407732018WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.9
295407732018WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.9
279582892017WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.0
279582892017WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation.0
271535522016miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth.25
275427362016WSB1: from homeostasis to hypoxia.18
271535522016miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth.25

Citation

Dessen P

WSB1 (WD repeat and SOCS box containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50319