FAAH (fatty acid amide hydrolase)

2008-09-01  

Identity

HGNC
FAAH
LOCATION
1p33
LOCUSID
2166
ALIAS
FAAH-1,PSAB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2166
MIM: 602935
HGNC: 3553
Ensembl: ENSG00000117480

Variants:

dbSNP: 2166
ClinVar: 2166
TCGA: ENSG00000117480
COSMIC: FAAH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117480ENST00000243167O00519
ENSG00000117480ENST00000484697A0A087WYA0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD20631561
PA131890620cannabinoidsChemicalClinicalAnnotationassociatedPD17290447
PA444702KyphosisDiseaseVariantAnnotationassociatedPD
PA445522Respiratory InsufficiencyDiseaseVariantAnnotationambiguousPD
PA445619ScoliosisDiseaseVariantAnnotationassociatedPD
PA446876Substance-Related DisordersDiseaseClinicalAnnotationassociatedPD17290447, 23556448, 31789429
PA446970Postoperative Nausea and VomitingDiseaseVariantAnnotationnot associatedPD
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD20631561
PA449061clozapineChemicalClinicalAnnotationassociatedPD20631561
PA449841haloperidolChemicalClinicalAnnotationassociatedPD20631561
PA449957ibuprofenChemicalPathwayassociated25502615
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD23556448, 31789429
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationambiguousPD
PA450688olanzapineChemicalClinicalAnnotationassociatedPD20631561
PA451201quetiapineChemicalClinicalAnnotationassociatedPD20631561
PA451257risperidoneChemicalClinicalAnnotationassociatedPD20631561
PA452618opioidsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
381148122024Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.0
381148122024Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.0
341711082023Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.6
359002942023Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.3
363008052023Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.2
363721842023Endocannabinoid hydrolases differentially distribute in platelets and red blood cells and are differentially released by thrombin.1
368688902023Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [(11)C]CURB in Heavy-Drinking Youth.3
370189742023The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.1
372537332023Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.2
373723432023Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.2
374332112023FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.0
377619662023Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.2
341711082023Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.6
359002942023Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.3
363008052023Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.2

Citation

Dessen P

FAAH (fatty acid amide hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50330/favicon/js/js/lib/bootstrap.min.js