CYTH2 (cytohesin 2)

2008-09-01  

Identity

HGNC
CYTH2
LOCATION
19q13.33
LOCUSID
9266
ALIAS
ARNO,CTS18,CTS18.1,PSCD2,PSCD2L,SEC7L,Sec7p-L,Sec7p-like,cytohesin-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9266
MIM: 602488
HGNC: 9502
Ensembl: ENSG00000105443

Variants:

dbSNP: 9266
ClinVar: 9266
TCGA: ENSG00000105443
COSMIC: CYTH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105443ENST00000325139F8W8E2
ENSG00000105443ENST00000391881G5E9B7
ENSG00000105443ENST00000427476A0A0D9SFG6
ENSG00000105443ENST00000452733Q99418
ENSG00000105443ENST00000460595A0A286YF81
ENSG00000105443ENST00000595765M0R2J0
ENSG00000105443ENST00000620214Q8WYS2
ENSG00000105443ENST00000641098Q99418

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
317804322020Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment.3
317804322020Molecular Architecture of a Network of Potential Intracellular EGFR Modulators: ARNO, CaM, Phospholipids, and the Juxtamembrane Segment.3
303554482018INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.12
303554482018INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.12
280079152017Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO.25
280079152017Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO.25
272031022016Lack of Evidence that CYTH2/ARNO Functions as a Direct Intracellular EGFR Activator.1
272031022016Lack of Evidence that CYTH2/ARNO Functions as a Direct Intracellular EGFR Activator.1
257368912015Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.22
263782522015ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment.6
257368912015Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.22
263782522015ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment.6
245814252014Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6.12
246187372014Cytohesins/ARNO: the function in colorectal cancer cells.17
245814252014Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6.12

Citation

Dessen P

CYTH2 (cytohesin 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50360/teaching-explorer/js/lib/favicon/favicon-32x32.png