Identity
HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
ADTKD5,HNFJ4,HSEC61,SEC61,SEC61A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29927
MIM: 609213
HGNC: 18276
Ensembl: ENSG00000058262
Variants:
dbSNP: 29927
ClinVar: 29927
TCGA: ENSG00000058262
COSMIC: SEC61A1
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38664472 | 2024 | Comparative analysis of SEC61A1 mutant R236C in two patient-derived cellular platforms. | 0 |
| 38664472 | 2024 | Comparative analysis of SEC61A1 mutant R236C in two patient-derived cellular platforms. | 0 |
| 35064074 | 2022 | Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin. | 9 |
| 35064074 | 2022 | Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin. | 9 |
| 34211117 | 2021 | An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum. | 26 |
| 34211117 | 2021 | An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum. | 26 |
| 32325141 | 2020 | Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia. | 15 |
| 32692975 | 2020 | Structure of the Inhibited State of the Sec Translocon. | 28 |
| 32325141 | 2020 | Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia. | 15 |
| 32692975 | 2020 | Structure of the Inhibited State of the Sec Translocon. | 28 |
| 31197453 | 2019 | Aberrant expression of Sec61α in esophageal cancers. | 1 |
| 31197453 | 2019 | Aberrant expression of Sec61α in esophageal cancers. | 1 |
| 28782633 | 2018 | Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). | 34 |
| 29540678 | 2018 | Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. | 38 |
| 29915147 | 2018 | Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature. | 33 |
Citation
Dessen P
SEC61A1 (SEC61 translocon subunit alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-09-01
Online version: http://atlasgeneticsoncology.org/gene/50367/sec61a1
