Identity
HGNC
LOCATION
14q22.2
LOCUSID
ALIAS
DYT14,DYT5,DYT5a,GCH,GTP-CH-1,GTPCH1,HPABH4B
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2643
MIM: 600225
HGNC: 4193
Ensembl: ENSG00000131979
Variants:
dbSNP: 2643
ClinVar: 2643
TCGA: ENSG00000131979
COSMIC: GCH1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38084654 | 2024 | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | 0 |
| 38757341 | 2024 | Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells. | 0 |
| 38084654 | 2024 | Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. | 0 |
| 38757341 | 2024 | Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells. | 0 |
| 37463466 | 2023 | GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner. | 1 |
| 37463466 | 2023 | GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner. | 1 |
| 34674384 | 2022 | Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease. | 3 |
| 36266731 | 2022 | CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. | 35 |
| 36399957 | 2022 | Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo. | 4 |
| 34674384 | 2022 | Association analysis of SYT11, FGF20, GCH1 rare variants in Parkinson's disease. | 3 |
| 36266731 | 2022 | CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. | 35 |
| 36399957 | 2022 | Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo. | 4 |
| 32363908 | 2021 | Oxidative Stress, GTPCH1, and Endothelial Nitric Oxide Synthase Uncoupling in Hypertension. | 35 |
| 32662044 | 2021 | Association of TOR1A and GCH1 Polymorphisms with Isolated Dystonia in India. | 1 |
| 33087420 | 2021 | Brain structural alterations in patients with GCH1 mutations associated DOPA-responsive dystonia. | 0 |
Citation
Dessen P
GCH1 (GTP cyclohydrolase 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/50399/gch1
