Identity
HGNC
LOCATION
16p12.2
LOCUSID
ALIAS
BESC1,ENaCb,ENaCbeta,LIDLS1,SCNEB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6338
MIM: 600760
HGNC: 10600
Ensembl: ENSG00000168447
Variants:
dbSNP: 6338
ClinVar: 6338
TCGA: ENSG00000168447
COSMIC: SCNN1B
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134875400 | WNK4 | Gene | Pathway | associated | 23788015 | ||
| PA165815771 | Farglitazar | Chemical | ClinicalAnnotation | associated | PD | 18004211 | |
| PA31534 | NEDD4L | Gene | Pathway | associated | 23788015 | ||
| PA33782 | WNK1 | Gene | Pathway | associated | 23788015 | ||
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PD | 18004211 | |
| PA448368 | amiloride | Chemical | Pathway | associated | 23788015 | ||
| PA449782 | glibenclamide | Chemical | ClinicalAnnotation | associated | PD | 18004211 | |
| PA451752 | triamterene | Chemical | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36564468 | 2023 | The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade. | 4 |
| 36774301 | 2023 | Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome. | 1 |
| 36899055 | 2023 | Genetic variation in salt taste receptors impact salt intake and blood pressure. | 0 |
| 37477776 | 2023 | SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts. | 0 |
| 36564468 | 2023 | The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade. | 4 |
| 36774301 | 2023 | Identification of a novel frameshift mutation in the SCNN1B causing Liddle syndrome. | 1 |
| 36899055 | 2023 | Genetic variation in salt taste receptors impact salt intake and blood pressure. | 0 |
| 37477776 | 2023 | SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts. | 0 |
| 35462606 | 2022 | Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting. | 5 |
| 36193739 | 2022 | Rare Variants in Genes Encoding Subunits of the Epithelial Na(+) Channel Are Associated With Blood Pressure and Kidney Function. | 10 |
| 35462606 | 2022 | Downregulation of epithelial sodium channel (ENaC) activity in cystic fibrosis cells by epigenetic targeting. | 5 |
| 36193739 | 2022 | Rare Variants in Genes Encoding Subunits of the Epithelial Na(+) Channel Are Associated With Blood Pressure and Kidney Function. | 10 |
| 33916525 | 2021 | DNA Methylation Patterns Correlate with the Expression of SCNN1A, SCNN1B, and SCNN1G (Epithelial Sodium Channel, ENaC) Genes. | 9 |
| 34111567 | 2021 | Integrative analyses identified ion channel genes GJB2 and SCNN1B as prognostic biomarkers and therapeutic targets for lung adenocarcinoma. | 15 |
| 34223773 | 2021 | A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome. | 2 |
Citation
Dessen P
SCNN1B (sodium channel epithelial 1 subunit beta)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/50400/scnn1b
