PKP3 (plakophilin 3)

2008-10-01  

Identity

HGNC
PKP3
LOCATION
11p15.5
LOCUSID
11187
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11187
MIM: 605561
HGNC: 9025
Ensembl: ENSG00000184363

Variants:

dbSNP: 11187
ClinVar: 11187
TCGA: ENSG00000184363
COSMIC: PKP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184363ENST00000331563Q9Y446
ENSG00000184363ENST00000525642H0YEY5
ENSG00000184363ENST00000527442E9PJR7
ENSG00000184363ENST00000528036E9PRW6
ENSG00000184363ENST00000531857E9PK71
ENSG00000184363ENST00000533249E9PKC4
ENSG00000184363ENST00000534401E9PQ15

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380487792024Role and function of plakophilin 3 in cancer progression and skin disease.1
380487792024Role and function of plakophilin 3 in cancer progression and skin disease.1
344158212022Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells.0
344158212022Disease-related blood-based differential methylation in cystic fibrosis and its representation in lung cancer revealed a regulatory locus in PKP3 in lung epithelial cells.0
340584722021A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.8
342602812021Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex.4
340584722021A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt pathway components and signals.8
342602812021Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex.4
305278042019PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.22
305278042019PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.22
291461822018Plakophilin3 increases desmosome assembly, size and stability by increasing expression of desmocollin2.6
29678907201814-3-3 proteins regulate desmosomal adhesion via plakophilins.10
297224222018Expression of plakophilin 3 in diffuse malignant pleural mesothelioma.2
298037402018Plakophilin3 loss leads to an increase in lipocalin2 expression, which is required for tumour formation.9
301441762018Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis.13

Citation

Dessen P

PKP3 (plakophilin 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50409