CLEC7A (C-type lectin domain containing 7A)

2008-10-01  

Identity

HGNC
CLEC7A
LOCATION
12p13.2
LOCUSID
64581
ALIAS
BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2

Other Information

Locus ID:

NCBI: 64581
MIM: 606264
HGNC: 14558
Ensembl: ENSG00000172243

Variants:

dbSNP: 64581
ClinVar: 64581
TCGA: ENSG00000172243
COSMIC: CLEC7A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172243ENST00000298523Q9BXN2
ENSG00000172243ENST00000304084Q9BXN2
ENSG00000172243ENST00000304084A0A024RAN9
ENSG00000172243ENST00000310002Q9BXN2
ENSG00000172243ENST00000310002A0A0S2Z5Q1
ENSG00000172243ENST00000349926Q9BXN2
ENSG00000172243ENST00000353231Q9BXN2
ENSG00000172243ENST00000396484Q9BXN2
ENSG00000172243ENST00000465100Q9BXN2
ENSG00000172243ENST00000525605Q68D78
ENSG00000172243ENST00000529761Q9BXN2
ENSG00000172243ENST00000529761A0A024RAN9
ENSG00000172243ENST00000531192Q9BXN2
ENSG00000172243ENST00000533022Q9BXN2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764

References

Pubmed IDYearTitleCitations
382287172024Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks.0
382528182024Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing.0
384595412024Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.2
389075412024IL-17A and TNF-α-induced Dectin-1 expression may promote keratinocyte proliferation in psoriatic lesions.0
382287172024Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks.0
382528182024Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing.0
384595412024Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.2
389075412024IL-17A and TNF-α-induced Dectin-1 expression may promote keratinocyte proliferation in psoriatic lesions.0
369320822023Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.8
375153242023Dectin-1 multimerization and signaling depends on fungal β-glucan structure and exposure.1
380558192023DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.0
369320822023Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.8
375153242023Dectin-1 multimerization and signaling depends on fungal β-glucan structure and exposure.1
380558192023DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.0
339822902022Epigenetic regulation of epithelial dectin-1 through an IL-33-STAT3 axis in allergic disease.4

Citation

Dessen P

CLEC7A (C-type lectin domain containing 7A)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50429