GUK1 (guanylate kinase 1)

2008-10-01  

Identity

HGNC
GUK1
LOCATION
1q42.13
LOCUSID
2987
ALIAS
GMK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2987
MIM: 139270
HGNC: 4693
Ensembl: ENSG00000143774

Variants:

dbSNP: 2987
ClinVar: 2987
TCGA: ENSG00000143774
COSMIC: GUK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143774ENST00000312726Q16774
ENSG00000143774ENST00000312726Q6IBG8
ENSG00000143774ENST00000366716Q16774
ENSG00000143774ENST00000366716Q6IBG8
ENSG00000143774ENST00000366718Q16774
ENSG00000143774ENST00000366718Q6IBG8
ENSG00000143774ENST00000366721B1ANH5
ENSG00000143774ENST00000366722B1ANH6
ENSG00000143774ENST00000366723B1ANG9
ENSG00000143774ENST00000366726Q16774
ENSG00000143774ENST00000366726Q6IBG8
ENSG00000143774ENST00000366728Q16774
ENSG00000143774ENST00000366730Q16774
ENSG00000143774ENST00000366730Q6IBG8
ENSG00000143774ENST00000391865Q16774
ENSG00000143774ENST00000412265B1ANH2
ENSG00000143774ENST00000435153B1ANH3
ENSG00000143774ENST00000453943B1ANH0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir metabolismREACTOMER-HSA-2161541

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.2
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.2
168325842006Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.4
168325842006Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.4

Citation

Dessen P

GUK1 (guanylate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50432/guk1