SNCAIP (synuclein alpha interacting protein)

2008-12-01  

Identity

HGNC
SNCAIP
LOCATION
5q23.2
LOCUSID
9627
ALIAS
SYPH1,Sph1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9627
MIM: 603779
HGNC: 11139
Ensembl: ENSG00000064692

Variants:

dbSNP: 9627
ClinVar: 9627
TCGA: ENSG00000064692
COSMIC: SNCAIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064692ENST00000261367Q9Y6H5
ENSG00000064692ENST00000261368Q9Y6H5
ENSG00000064692ENST00000379538Q9Y6H5
ENSG00000064692ENST00000395466Q6L981
ENSG00000064692ENST00000395469Q9Y6H5
ENSG00000064692ENST00000414317Q6L980
ENSG00000064692ENST00000504884Q6L981
ENSG00000064692ENST00000506272D6RFL3
ENSG00000064692ENST00000508017Q6L982
ENSG00000064692ENST00000508681D6RBR2
ENSG00000064692ENST00000509023Q6L980
ENSG00000064692ENST00000509154D6R9G8
ENSG00000064692ENST00000509652D6RHX3
ENSG00000064692ENST00000510658Q6L982
ENSG00000064692ENST00000512146Q6L983
ENSG00000064692ENST00000512385Q6L982
ENSG00000064692ENST00000514467D6RD29
ENSG00000064692ENST00000514497D6REC1
ENSG00000064692ENST00000515215Q6L982
ENSG00000064692ENST00000542191Q6L983

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Parkinson's diseaseKEGGhsa05012
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
387001502024Exploring Structural Insights of Aβ42 and α-Synuclein Monomers and Heterodimer: A Comparative Study Using Implicit and Explicit Solvent Simulations.0
387001502024Exploring Structural Insights of Aβ42 and α-Synuclein Monomers and Heterodimer: A Comparative Study Using Implicit and Explicit Solvent Simulations.0
303169842019Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson's disease model cells by inhibiting ROS production and apoptosis.12
303169842019Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson's disease model cells by inhibiting ROS production and apoptosis.12
264659222016Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.21
264659222016Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.21
248290962014Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.5
255452462014Synphilin-1 binds ATP and regulates intracellular energy status.6
248290962014Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.5
255452462014Synphilin-1 binds ATP and regulates intracellular energy status.6
228289402012Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model.23
228289402012Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model.23
208167812011α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.12
211039072011Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.16
213442402011Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.5

Citation

Dessen P

SNCAIP (synuclein alpha interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50484/case-report-explorer/teaching-explorer/js/web-card-_common.js