Identity
HGNC
LOCATION
5q21.3
LOCUSID
ALIAS
FBXO13,Fbl17,Fbx13
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64839
MIM: 609083
HGNC: 13615
Ensembl: ENSG00000145743
Variants:
dbSNP: 64839
ClinVar: 64839
TCGA: ENSG00000145743
COSMIC: FBXL17
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000145743 | ENST00000496714 | Q9UF56 |
| ENSG00000145743 | ENST00000542267 | Q9UF56 |
| ENSG00000145743 | ENST00000619412 | H7C835 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31560077 | 2020 | Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. | 9 |
| 32814905 | 2020 | Structural basis for dimerization quality control. | 19 |
| 31560077 | 2020 | Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation. | 9 |
| 32814905 | 2020 | Structural basis for dimerization quality control. | 19 |
| 27234298 | 2016 | SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. | 35 |
| 27234298 | 2016 | SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. | 35 |
| 24035498 | 2013 | Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. | 61 |
| 24035498 | 2013 | Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. | 61 |
| 20200978 | 2010 | Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. | 8 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20200978 | 2010 | Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. | 8 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 18820369 | 2008 | Identification of F-box/LLR-repeated protein 17 as potential useful biomarker for breast cancer therapy. | 8 |
| 18820369 | 2008 | Identification of F-box/LLR-repeated protein 17 as potential useful biomarker for breast cancer therapy. | 8 |
Citation
Dessen P
FBXL17 (F-box and leucine rich repeat protein 17)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50499/fbxl17
