CHRM3 (cholinergic receptor muscarinic 3)

2008-12-01 Affiliation

Identity

HGNC

CHRM3

LOCATION

1q43

LOCUSID

1131

ALIAS

EGBRS,HM3,PBS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1131
MIM: 118494
HGNC: 1952
Ensembl: ENSG00000133019

Variants:

dbSNP: 1131
ClinVar: 1131
TCGA: ENSG00000133019
COSMIC: CHRM3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133019	ENST00000255380	P20309
ENSG00000133019	ENST00000255380	A0A024R3S2
ENSG00000133019	ENST00000448020	B1AN12
ENSG00000133019	ENST00000615928	P20309
ENSG00000133019	ENST00000615928	A0A024R3S2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Regulation of actin cytoskeleton	KEGG	ko04810
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Regulation of actin cytoskeleton	KEGG	hsa04810
Salivary secretion	KEGG	ko04970
Salivary secretion	KEGG	hsa04970
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Cholinergic synapse	KEGG	hsa04725
Insulin secretion	KEGG	hsa04911
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Muscarinic acetylcholine receptors	REACTOME	R-HSA-390648
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Acetylcholine regulates insulin secretion	REACTOME	R-HSA-399997

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38010846	2024	Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.	1
38010846	2024	Associations of genetic variations in the M3 receptor with salt sensitivity, longitudinal changes in blood pressure and the incidence of hypertension in Chinese adults.	1
36919835	2023	CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.	1
37175905	2023	Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?	2
36919835	2023	CHRM3-Associated miRNAs May Play a Role in Bile Acid-Induced Proliferation of H508 Colon Cancer Cells.	1
37175905	2023	Muscarinic Acetylcholine Receptor M3 Expression and Survival in Human Colorectal Carcinoma-An Unexpected Correlation to Guide Future Treatment?	2
34935917	2022	Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.	3
35967390	2022	Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.	4
34935917	2022	Methylation-reprogrammed CHRM3 results in vascular dysfunction in the human umbilical vein following IVF-ET†.	3
35967390	2022	Impaired sweating in patients with cholinergic urticaria is linked to low expression of acetylcholine receptor CHRM3 and acetylcholine esterase in sweat glands.	4
35673819	2021	Expression of M3 muscarinic acetylcholine receptors in gastric cancer.	1
35673819	2021	Expression of M3 muscarinic acetylcholine receptors in gastric cancer.	1
31584702	2020	Muscarinic receptor M3 contributes to vascular and neural growth factor up-regulation in severe asthma.	0
32205868	2020	Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.	16
32614803	2020	M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome.	3

Citation

Dessen P

CHRM3 (cholinergic receptor muscarinic 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50505