AHCY (adenosylhomocysteinase)

2008-12-01  

Identity

HGNC
AHCY
LOCATION
20q11.22
LOCUSID
191
ALIAS
SAHH,adoHcyase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 191
MIM: 180960
HGNC: 343
Ensembl: ENSG00000101444

Variants:

dbSNP: 191
ClinVar: 191
TCGA: ENSG00000101444
COSMIC: AHCY

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101444ENST00000217426P23526
ENSG00000101444ENST00000217426A0A384MTQ3
ENSG00000101444ENST00000538132P23526

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Methionine degradationKEGGhsa_M00035
Methionine degradationKEGGM00035
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2SeREACTOMER-HSA-2408508

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380644082024Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells.0
380644082024Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells.0
375805402023Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.4
380032922023Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells.0
375805402023Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.4
380032922023Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt Signaling Pathway in SW480 Cells.0
324926982021Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.1
337538542021Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.1
339153032021Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening.4
343264692021Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.14
324926982021Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile.1
337538542021Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.1
339153032021Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening.4
343264692021Genomic and transcriptomic profiling of hepatoid adenocarcinoma of the stomach.14
320208472020DNA methylation of AHCY may increase the risk of ischemic stroke.10

Citation

Dessen P

AHCY (adenosylhomocysteinase)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50513