CBR1 (carbonyl reductase 1)

2008-12-01  

Identity

HGNC
CBR1
LOCATION
21q22.12
LOCUSID
873
ALIAS
CBR,PG-9-KR,SDR21C1,hCBR1

Other Information

Locus ID:

NCBI: 873
MIM: 114830
HGNC: 1548
Ensembl: ENSG00000159228

Variants:

dbSNP: 873
ClinVar: 873
TCGA: ENSG00000159228
COSMIC: CBR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159228ENST00000290349P16152
ENSG00000159228ENST00000290349A0A384NL53
ENSG00000159228ENST00000399191A8MTM1
ENSG00000159228ENST00000439427E9PQ63
ENSG00000159228ENST00000530908P16152

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Arachidonic acid metabolismKEGGhsa00590
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD22124095
PA165291922doxorubicinolChemicalClinicalAnnotationassociatedPK19016765
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPKPD19016765, 19022938
PA445018CardiomyopathiesDiseaseClinicalAnnotationassociatedPD22124095
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD22124095
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449212daunorubicinChemicalVariantAnnotationassociatedPK19204081
PA449412doxorubicinChemicalClinicalAnnotation, Pathway, VariantAnnotationassociatedPKPD19016765, 19022938, 19204081, 21048526

References

Pubmed IDYearTitleCitations
379054832023[Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps].0
379054832023[Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps].0
362060982022LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p.1
362060982022LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p.1
339640002021Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation.7
339640002021Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation.7
317596322020Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group.3
327673992020Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta.3
317596322020Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group.3
327673992020Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta.3
298511332018CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver.2
303768622018Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma.14
298511332018CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver.2
303768622018Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma.14
282747192017Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes.3

Citation

Dessen P

CBR1 (carbonyl reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50526