Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 873
MIM: 114830
HGNC: 1548
Ensembl: ENSG00000159228
Variants:
dbSNP: 873
ClinVar: 873
TCGA: ENSG00000159228
COSMIC: CBR1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | ||
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 22124095 | |
| PA165291922 | doxorubicinol | Chemical | ClinicalAnnotation | associated | PK | 19016765 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 19016765, 19022938 |
| PA445018 | Cardiomyopathies | Disease | ClinicalAnnotation | associated | PD | 22124095 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 22124095 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449212 | daunorubicin | Chemical | VariantAnnotation | associated | PK | 19204081 | |
| PA449412 | doxorubicin | Chemical | ClinicalAnnotation, Pathway, VariantAnnotation | associated | PK | PD | 19016765, 19022938, 19204081, 21048526 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37905483 | 2023 | [Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps]. | 0 |
| 37905483 | 2023 | [Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps]. | 0 |
| 36206098 | 2022 | LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p. | 1 |
| 36206098 | 2022 | LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p. | 1 |
| 33964000 | 2021 | Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. | 7 |
| 33964000 | 2021 | Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. | 7 |
| 31759632 | 2020 | Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group. | 3 |
| 32767399 | 2020 | Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta. | 3 |
| 31759632 | 2020 | Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group. | 3 |
| 32767399 | 2020 | Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta. | 3 |
| 29851133 | 2018 | CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver. | 2 |
| 30376862 | 2018 | Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. | 14 |
| 29851133 | 2018 | CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver. | 2 |
| 30376862 | 2018 | Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma. | 14 |
| 28274719 | 2017 | Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes. | 3 |
Citation
Dessen P
CBR1 (carbonyl reductase 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-12-01
Online version: http://atlasgeneticsoncology.org/gene/50526/cbr1
