ALPP (alkaline phosphatase, placental)

2008-12-01  

Identity

HGNC
ALPP
LOCATION
2q37.1
LOCUSID
250
ALIAS
ALP,ALPI,IAP,PALP,PLAP,PLAP-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 250
MIM: 171800
HGNC: 439
Ensembl: ENSG00000163283

Variants:

dbSNP: 250
ClinVar: 250
TCGA: ENSG00000163283
COSMIC: ALPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163283ENST00000392027P05187

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Folate biosynthesisKEGGko00790
Thiamine metabolismKEGGhsa00730
Folate biosynthesisKEGGhsa00790
Metabolic pathwaysKEGGhsa01100
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379523102024Role of serum alkaline phosphatase as a potential biomarker of severity and prognosis in intracerebral hemorrhage.0
379523102024Role of serum alkaline phosphatase as a potential biomarker of severity and prognosis in intracerebral hemorrhage.0
367637252023Alkaline Phosphatase is an Independent Risk Factor for Periprosthetic Fractures in Total Joint Arthroplasty.0
367637252023Alkaline Phosphatase is an Independent Risk Factor for Periprosthetic Fractures in Total Joint Arthroplasty.0
329061152021Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor.8
329188062021Extremely high levels of alkaline phosphatase and pregnancy outcome: case series and review of the literature.3
343633252021Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.8
344283612021Cross-sectional analysis: clinical presentation of children with persistently low ALP levels.2
348312332021Development and Characterization of Alkaline Phosphatase-Positive Human Umbilical Cord Perivascular Cells.2
329061152021Diagnostic Capability of Cerebrospinal Fluid-Placental Alkaline Phosphatase Value in Intracranial Germ Cell Tumor.8
329188062021Extremely high levels of alkaline phosphatase and pregnancy outcome: case series and review of the literature.3
343633252021Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.8
344283612021Cross-sectional analysis: clinical presentation of children with persistently low ALP levels.2
348312332021Development and Characterization of Alkaline Phosphatase-Positive Human Umbilical Cord Perivascular Cells.2
324727572020PLAP -CAR T cells mediate high specific cytotoxicity against colon cancer cells.12

Citation

Dessen P

ALPP (alkaline phosphatase, placental)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50534