CAPN6 (calpain 6)

2008-12-01  

Identity

HGNC
CAPN6
LOCATION
Xq23
LOCUSID
827
ALIAS
CANPX,CAPNX,CalpM,DJ914P14.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 827
MIM: 300146
HGNC: 1483
Ensembl: ENSG00000077274

Variants:

dbSNP: 827
ClinVar: 827
TCGA: ENSG00000077274
COSMIC: CAPN6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077274ENST00000324068Q9Y6Q1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228

References

Pubmed IDYearTitleCitations
372437582023Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6.0
372437582023Advanced glycation end products promote the progression of chronic kidney diseases by targeting calpain 6.0
361533202022A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases.1
361533202022A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases.1
328520772021The investigation of calpain in human placenta with fetal growth restriction.1
328520772021The investigation of calpain in human placenta with fetal growth restriction.1
321610092020CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway.4
321610092020CAPN6 Regulates Uterine Leiomyoma Cell Proliferation and Apoptosis through the Rac1-Dependent Signaling Pathway.4
316730712019Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion.5
316730712019Non-proteolytic calpain-6 interacts with VEGFA and promotes angiogenesis by increasing VEGF secretion.5
263754402016miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.30
275254422016Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.16
263754402016miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1.30
275254422016Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.16
216817442012Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma.17

Citation

Dessen P

CAPN6 (calpain 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50536/haematological-explorer/cancer-prone-explorer/css/card-gene.css