PLXND1 (plexin D1)

2008-12-01  

Identity

HGNC
PLXND1
LOCATION
3q22.1
LOCUSID
23129
ALIAS
PLEXD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23129
MIM: 604282
HGNC: 9107
Ensembl: ENSG00000004399

Variants:

dbSNP: 23129
ClinVar: 23129
TCGA: ENSG00000004399
COSMIC: PLXND1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004399ENST00000324093Q9Y4D7
ENSG00000004399ENST00000504689D6RH25
ENSG00000004399ENST00000505237H0YA64
ENSG00000004399ENST00000505665H0Y9D1
ENSG00000004399ENST00000506979H0YAM9
ENSG00000004399ENST00000512744H0YAB2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
353969972023Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans.2
370734252023Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.3
353969972023Biallelic alterations in PLXND1 cause common arterial trunk and other cardiac malformations in humans.2
370734252023Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.3
342970342022Identification of plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis.4
347912162022Association of PLXND1 with a novel subtype of anomalous pulmonary venous return.1
359170122022PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer.2
342970342022Identification of plexin D1 on circulating extracellular vesicles as a potential biomarker of polymyositis and dermatomyositis.4
347912162022Association of PLXND1 with a novel subtype of anomalous pulmonary venous return.1
359170122022PLXND1/SEMA3E Promotes Epithelial-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer.2
329719282020Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner.9
329719282020Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner.9
311528242019Divergent roles of Plexin D1 in cancer.15
311528242019Divergent roles of Plexin D1 in cancer.15
285542712018Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study.5

Citation

Dessen P

PLXND1 (plexin D1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50545