DTX3L (deltex E3 ubiquitin ligase 3L)

2008-12-01  

Identity

HGNC
DTX3L
LOCATION
3q21.1
LOCUSID
151636
ALIAS
BBAP,RNF143
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 151636
MIM: 613143
HGNC: 30323
Ensembl: ENSG00000163840

Variants:

dbSNP: 151636
ClinVar: 151636
TCGA: ENSG00000163840
COSMIC: DTX3L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163840ENST00000296161Q8TDB6
ENSG00000163840ENST00000383661Q8TDB6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374608622024DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT Axis.1
380003902024DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.4
374608622024DTX3L Accelerates Pancreatic cancer Progression via FAK/PI3K/AKT Axis.1
380003902024DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids.4
377745672023DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer.0
377745672023DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer.0
343585602021The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.57
343585602021The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.57
285257422017Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.101
286276342017DTX3L is upregulated in glioma and is associated with glioma progression.7
286538812017Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells.9
285257422017Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.101
286276342017DTX3L is upregulated in glioma and is associated with glioma progression.7
286538812017Effects of DTX3L on the cell proliferation, adhesion, and drug resistance of multiple myeloma cells.9
247900972014The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.25

Citation

Dessen P

DTX3L (deltex E3 ubiquitin ligase 3L)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50567